Design selective glutamate dehydrogenase inhibitors?: To what extent is it possible to

Design selective glutamate dehydrogenase inhibitors?: To what extent is it possible to

ISBN10: 3844301585
ISBN13: 978-3844301588
Author: -
Title: Design selective glutamate dehydrogenase inhibitors?: To what extent is it possible to
Publisher: LAP LAMBERT Academic Publishing (February 10, 2011)
Language: English
Size ePub: 1558 kb
Size PDF: 1816 kb
Rating: 4.9/5
Votes: 515
Pages: 132 pages
Subcategory: Biological Sciences

Design selective glutamate dehydrogenase inhibitors?: To what extent is it possible to



Plasmodium falciparum glutamate dehydrogenase (GDH) is an attractive target for the rational development of new antimalarial drugs. Enzyme Kinetics assays and molecular modelling technology were used to measure inhibition effects for some ligands on two different GDHs. The study presented in this work provided a base line for future explorations and discoveries of the inhibition selectivity between Plasmodium and human GDH based on bacterial and mammalian animal GDH.

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